Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Sunday, 12 / 16 / 2018

Articles

Table of Content

Category: Vol 6 Issue 3
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Table of Contents

Original Article

CA-125 Significance in Cirrhosis and Correlation with Disease Severity and Portal Hypertension: A Retrospective Study
Raja GR Edula, Sujit Muthukuru, Serban Moroianu, Yucai Wang, Vivek Lingiah, Phoenix Fung, Nikolaos T Pyrsopoulos
Abstract ] [ Html ] [ PDF Full-text ] 241-246 Doi: 10.14218/JCTH.2017.00070

Elimination of Hepatitis C in Liver Transplant Recipients
Sammy Saab, Youssef Challita, Phillip H. Chen, Melissa A. Jimenez, Alex D. Lee, Elena G. Saab, Timothy Ahn, Gina Choi, Francisco A. Durazo, Mohamed M. El-Kabany, Steven-Huy B. Han, Jonathan Grotts, Vatche G. Agopian, Ronald W. Busuttil
Abstract ] [ Html ] [ PDF Full-text ] 247-250 Doi: 10.14218/JCTH.2017.00079

Microwave Ablation in Intermediate Hepatocellular Carcinoma in Cirrhosis: An Italian Multicenter Prospective Study
Antonio Giorgio, Pietro Gatti, Luca Montesarchio, Maria Gabriella Merola, Ferdinando Amendola, Andrea Calvanese, Gaetano Iaquinto, Massimiliano Fontana, Emanuela Ciracì, Stefano Semeraro, Bruno Santoro, Carmine Coppola, Paolo Matteucci, Valentina Giorgio
Abstract ] [ Html ] [ PDF Full-text ] 251-257 Doi: 10.14218/JCTH.2018.00013

Hepatitis C Virus Clearance by Direct-acting Antiviral Results in Rapid Resolution of Hepatocytic Injury as Indicated by Both Alanine Aminotransferase and Aspartate Aminotransferase Normalization
Tung Huynh, Johnathan Zhang, Ke-Qin Hu
Abstract ] [ Html ] [ PDF Full-text ] 258-263 Doi: 10.14218/JCTH.2018.00014

Review Article

Future Pharmacotherapy for Non-alcoholic Steatohepatitis (NASH): Review of Phase 2 and 3 Trials 
James J. Connolly, Kohtaro Ooka, Joseph K. Lim
Abstract ] [ Html ] [ PDF Full-text ] 264-275 Doi: 10.14218/JCTH.2017.00056

Normothermic Ex-vivo Liver Perfusion and the Clinical Implications for Liver Transplantation 
Clifford Akateh, Eliza W. Beal, Bryan A. Whitson, Sylvester M. Black
Abstract ] [ Html ] [ PDF Full-text ] 276-282 Doi: 10.14218/JCTH.2017.00048

Liver Transplantation for Hepatitis B Virus-related Hepatocellular Carcinoma in Hong Kong 
Ka Wing Ma, Kenneth Siu Ho Chok, James Yan Yue Fung, Chung Mau Lo
Abstract ] [ Html ] [ PDF Full-text ] 283-288 Doi: 10.14218/JCTH.2017.00058

Refining the Role of Simultaneous Liver Kidney Transplantation 
Sabiha M. Hussain, Kalathil K. Sureshkumar
Abstract ] [ Html ] [ PDF Full-text ] 289-295 Doi: 10.14218/JCTH.2017.00065

HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation 
Marianna G. Mavilia, George Y. Wu
Abstract ] [ Html ] [ PDF Full-text ] 296-305 Doi: 10.14218/JCTH.2018.00016

A Systematic Literature Review of Syphilitic Hepatitis in Adults 
Jiaofeng Huang, Su Lin, Bo Wan, Yueyong Zhu
Abstract ] [ Html ] [ PDF Full-text ] 306-309 Doi: 10.14218/JCTH.2018.00003

Recent Advances Towards the Development of a Potent Antiviral Against the Hepatitis E Virus 
Saumya Anang, Nidhi Kaushik, Milan Surjit
Abstract ] [ Html ] [ PDF Full-text ] 310-316 Doi: 10.14218/JCTH.2018.00005

Candidate Biomarkers of Liver Fibrosis: A Concise, Pathophysiology-oriented Review 
Mattia Bellan, Luigi Mario Castello, Mario Pirisi
Abstract ] [ Html ] [ PDF Full-text ] 317-325 Doi: 10.14218/JCTH.2018.00006

The Genetics of Clinical Liver Diseases: Insight into the TM6SF2 E167K Variant 
Xiaoyu Zhang, Shousheng Liu, Quanjiang Dong, Yongning Xin, Shiying Xuan
Abstract ] [ Html ] [ PDF Full-text ] 326-331 Doi: 10.14218/JCTH.2018.00022

Role of SREBPs in Liver Diseases: A Mini-review 
Azam Moslehi, Zeinab Hamidi-zad
Abstract ] [ Html ] [ PDF Full-text ] 332-338 Doi: 10.14218/JCTH.2017.00061

Case Report

Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma
Düriye Betül Yılmaz, Zeynep Bayramoğlu, Gülşah Ünay, Erdem Ayık, Cumhur İbrahim Başsorgun, Gülsüm Özlem Elpek
Abstract ] [ Html ] [ PDF Full-text ] 339-344 Doi: 10.14218/JCTH.2017.00076

Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma

Category: Vol 6 Issue 3
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CASE REPORT

Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma

Düriye Betül Yılmaz, Zeynep Bayramoğlu, Gülşah Ünay, Erdem Ayık, Cumhur İbrahim Başsorgun and Gülsüm Özlem Elpek

Department of Pathology, Akdeniz University Medical School, Konyaalti/Antalya, Turkey

*Correspondence to: Gülsüm Özlem Elpek, Department of Pathology, Akdeniz University Medical School Hospital, Dumlupinar Street, Pinarbasi District, Konyaalti/Antalya-07070, Turkey. Tel: +90-242-249-6389, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(3):339-344 DOI: 10.14218/JCTH.2017.00076
Received: November 29, 2017 Accepted: April 6, 2018 Published online: June 28, 2018

Abstract

The composite tumors of the liver are very rare, including the coexistence of HCC (hepatocellular carcinoma) with NEC (neuroendocrine carcinoma). The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics, behaviors and treatments. Herein is described an incidental collision tumor of HCC-NEC, along with a review of the literature focusing on their clinicopathological findings and prognosis. The tumor presented here was found incidentally in the hepatectomy specimen of a 56-year-old man who had undergone liver transplantation for rapidly progressive liver failure because of alcoholic hepatitis and cirrhosis. Imaging and laboratory examinations did not demonstrate tumor-related findings. During macroscopic examination, two sharply defined and distinctive areas (1.7 cm and 0.6 cm dimension respectively) were detected among the cirrhotic nodules. The characteristic histopathological features and immunohistochemical findings allowed a diagnosis of HCC-NEC to be made. There was no evidence of recurrence and metastasis after 10 months following surgery. The present case and review revealed that these tumors are frequently found in older ages and males. Although serum markers are valuable in the discrimination of malignant tumors, their absence cannot completely rule out composite HCC-NEC. Diagnosis requires a comprehensive histopathological evaluation together with immunohistochemistry. The NEC component might influence the treatment strategy and eventually the outcome of the patient. In conclusion, the rare occurrence of HCC-NEC and the lack of diagnostic clinical signs and symptoms do not exclude their consideration in the differential diagnosis of liver tumors, especially in patients with the chronic liver disease.

Keywords

Liver neoplasm, Hepatocellular carcinoma, Neuroendocrine carcinoma

 

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 339-344  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

Role of SREBPs in Liver Diseases: A Mini-review

Category: Vol 6 Issue 3
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REVIEW ARTICLE

Role of SREBPs in Liver Diseases: A Mini-review

Azam Moslehi*, and Zeinab Hamidi-zad

Department of Physiology, Cellular & Molecular Research Center, Qom University of Medical Sciences, Qom, Iran

*Correspondence to: Azam Moslehi, Department of Physiology, Cellular & Molecular Research Center, Qom University of Medical Sciences, Qom 3713649373, Iran. Tel/fax: +98-25-37832470, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(3):332-338 DOI: 10.14218/JCTH.2017.00061
Received: September 18, 2017 Accepted: February 11, 2018 Published online: May 4, 2018

Abstract

Sterol regulator element binding proteins (SREBPs) are a family of transcription factors involved in the biogenesis of cholesterol, fatty acids and triglycerides. They also regulate physiological functions of many organs, such as thyroid, brain, heart, pancreas and hormone synthesis. Beside the physiological effects, SREBPs participate in some pathological processes, diabetes, endoplasmic reticulum stress, atherosclerosis and chronic kidney disease associated with SREBP expression changes. In the liver, SREBPs are involved in the pathogenesis of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatitis and hepatic cancer. There are several SREBP inhibitors that have potential for treating obesity, diabetes and cancer. This review assesses the recent findings about the roles of SREBPs in the physiology of organs’ function and pathogenesis of liver diseases.

Keywords

SREBP, Liver, Lipid

 

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 332-338  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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