Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Tuesday, 10 / 24 / 2017

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Table of Content

Category: Vol 5 Issue 3 Published on 07 September 2017 Super User
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Original Article

Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study
Hyun-Seok Kim, Laura Rotundo, Neil Kothari, Sung-Hoon Kim, Nikolaos Pyrsopoulos
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 185-192 Doi: 10.14218/JCTH.2017.00025

Rising Rate of Liver Transplantation in the Baby Boomer Generation with Non-alcoholic Steatohepatitis in the United States
Osama Siddique, Mairin Joseph-Talreja, Eric R. Yoo, Ryan B. Perumpail, George Cholankeril, Stephen A. Harrison, Zobair M. Younossi, Robert J. Wong, Aijaz Ahmed
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 193-196 Doi: 10.14218/JCTH.2017.00003

Diminishing Use of Liver Biopsy among Liver Transplant Recipients for Hepatitis C
Elizabeth Aby, Melissa A. Jimenez, Jonathan F. Grotts, Vatche Agopian, Samuel W. French, Ronald W. Busuttil, Sammy Saab
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 197-202 Doi: 10.14218/JCTH.2016.00073

Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis
Nora V. Bergasa, E. Anthony Jones
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 203-207 Doi: 10.14218/JCTH.2017.00001

Oral Co-administration of Soy-derived Extracts with Alcohol or with Sugar-sweetened Beverages Exerts Liver and Sugar Protective Effects
Tawfik Khoury, Devorah Rotnemer-Golinkin, Yehudit Shabat, Lidya Zolotarovya, Yaron Ilan
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 208-215 Doi: 10.14218/JCTH.2017.00019

Review Article

Non-alcoholic Fatty Liver Disease in Lean Subjects: Characteristics and Implications
Ramesh Kumar, Shantam Mohan
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 216-223 Doi: 10.14218/JCTH.2016.00068

18F-FDG-PET for Assessing Biological Viability and Prognosis in Liver Transplant Patients with Hepatocellular Carcinoma
Arno Kornberg, Martina Schernhammer, Helmut Friess
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 224-234 Doi: 10.14218/JCTH.2017.00014

Chemotherapy for Hepatocellular Carcinoma: Current Evidence and Future Perspectives
Emanuele Rinninella, Lucia Cerrito, Irene Spinelli, Marco Cintoni, Maria Cristina Mele, Maurizio Pompili, Antonio Gasbarrini
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 235-248 Doi: 10.14218/JCTH.2017.00002

Gut Microbiome-based Therapeutics in Liver Cirrhosis: Basic Consideration for the Next Step
Hiroshi Fukui
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 249-260 Doi: 10.14218/JCTH.2017.00008

Current Modalities of Fibrosis Assessment in Non-alcoholic Fatty Liver Disease
Mark CC Cheah, Arthur J McCullough, George Boon-Bee Goh
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 261-271 Doi: 10.14218/JCTH.2017.00009

Emerging Trends in Epidemiology of Hepatitis B Virus Infection
Cristina Stasi, Caterina Silvestri, Fabio Voller
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 272-276 Doi: 10.14218/JCTH.2017.00010

Current Scenario of Hepatitis B and Its Treatment in India
Gautam Ray
Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 277-296 Doi: 10.14218/JCTH.2017.00024

Volume 5 Issue 3, September 2017

Category: Vol 5 Issue 3 Published on 07 September 2017 Super User
Hits: 4800

scover V5I3  

Table of contents

Original Article

Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study
Hyun-Seok Kim, Laura Rotundo, Neil Kothari, Sung-Hoon Kim, Nikolaos Pyrsopoulos
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 185-192 Doi: 10.14218/JCTH.2017.00025

Rising Rate of Liver Transplantation in the Baby Boomer Generation with Non-alcoholic Steatohepatitis in the United States
Osama Siddique, Mairin Joseph-Talreja, Eric R. Yoo, Ryan B. Perumpail, George Cholankeril, Stephen A. Harrison, Zobair M. Younossi, Robert J. Wong, Aijaz Ahmed
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 193-196 Doi: 10.14218/JCTH.2017.00003

Diminishing Use of Liver Biopsy among Liver Transplant Recipients for Hepatitis C
Elizabeth Aby, Melissa A. Jimenez, Jonathan F. Grotts, Vatche Agopian, Samuel W. French, Ronald W. Busuttil, Sammy Saab
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 197-202 Doi: 10.14218/JCTH.2016.00073

Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis
Nora V. Bergasa, E. Anthony Jones
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 203-207 Doi: 10.14218/JCTH.2017.00001

Oral Co-administration of Soy-derived Extracts with Alcohol or with Sugar-sweetened Beverages Exerts Liver and Sugar Protective Effects
Tawfik Khoury, Devorah Rotnemer-Golinkin, Yehudit Shabat, Lidya Zolotarovya, Yaron Ilan
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 208-215 Doi: 10.14218/JCTH.2017.00019

Review Article

Non-alcoholic Fatty Liver Disease in Lean Subjects: Characteristics and Implications
Ramesh Kumar, Shantam Mohan
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 216-223 Doi: 10.14218/JCTH.2016.00068

18F-FDG-PET for Assessing Biological Viability and Prognosis in Liver Transplant Patients with Hepatocellular Carcinoma
Arno Kornberg, Martina Schernhammer, Helmut Friess
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 224-234 Doi: 10.14218/JCTH.2017.00014

Chemotherapy for Hepatocellular Carcinoma: Current Evidence and Future Perspectives
Emanuele Rinninella, Lucia Cerrito, Irene Spinelli, Marco Cintoni, Maria Cristina Mele, Maurizio Pompili, Antonio Gasbarrini
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 235-248 Doi: 10.14218/JCTH.2017.00002

Gut Microbiome-based Therapeutics in Liver Cirrhosis: Basic Consideration for the Next Step
Hiroshi Fukui
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 249-260 Doi: 10.14218/JCTH.2017.00008

Current Modalities of Fibrosis Assessment in Non-alcoholic Fatty Liver Disease
Mark CC Cheah, Arthur J McCullough, George Boon-Bee Goh
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 261-271 Doi: 10.14218/JCTH.2017.00009

Emerging Trends in Epidemiology of Hepatitis B Virus Infection
Cristina Stasi, Caterina Silvestri, Fabio Voller
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 272-276 Doi: 10.14218/JCTH.2017.00010

Current Scenario of Hepatitis B and Its Treatment in India
Gautam Ray
[ Abstract ] [ HTML Full-Text ] [ PDF Full-Text ] 277-296 Doi: 10.14218/JCTH.2017.00024

 

 

Current Scenario of Hepatitis B and Its Treatment in India

Category: Vol 5 Issue 3
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REVIEW ARTICLE

Current Scenario of Hepatitis B and Its Treatment in India

Gautam Ray*

Gastroenterology Unit, Department of Medicine, B.R.Singh Hospital, Kolkata, India

*Correspondence to: Gautam Ray, B.R.Singh Hospital, Sealdah, Kolkata 700014, West Bengal, India. Tel: +91-3323504075, Fax: +91-323507003, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2017;5(3):277-296 DOI: 10.14218/JCTH.2017.00024
Received: March 18, 2017 Accepted: June 3, 2017 Published online: July 8, 2017

Abstract

Hepatitis B is a significant public health problem in India, yet disease awareness is very low among the general population. The disease is mostly acquired horizontally, but the role of vertical transmission should not be underestimated. In spite of the fact that the majority of cases are e negative disease, most patients present in the advanced stage and even with hepatocellular carcinoma, the leading cause of which is hepatitis B. High-risk groups (especially tribals) also harbour significant disease burden and have a high prevalence of occult infection, supporting the potential of unknowingly spreading the disease. Findings on the relation of genotypes with disease severity or drug action have been conflicting. Though recently, oral antivirals with high genetic barrier to resistance have shown good viral suppression in the long term, e and s seroconversion is poor and relapse is universal upon therapy discontinuation. As no cure is possible with the currently available therapy, the target is long-term viral suppression by prolonged administration of oral antivirals; unfortunately, this leads to poor treatment adherence, which along with the high cost of therapy results in disease progression and spread of infection. At present, therefore, emphasis should be put on health education of the general and high-risk populations, along with health care workers to increase knowledge on such preventive measures as avoiding unsafe injection practices, high-risk sex, performing unnecessary injection and blood transfusion and providing proper screening of blood products; these efforts should be combined with intensive screening and aggressive vaccination programs, especially in high-risk groups and areas of high endemicity. Vaccination strategies are still below par and logistics should be developed for wider coverage; in addition, further research should be carried out on the efficacy and mode of usage for different types of vaccine.

Keywords

Hepatitis B, Epidemiology, Clinical, Prevention, Treatment, India

 

 

Journal of Clinical and Translational Hepatology 2017 vol. 5, 277-296 Html ] [ PDF Full-text ]

 

© The Authors 2017. This article is published under the terms of the Creative Commons Attribution-Noncommercial (CC BY-NC) License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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