Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Friday, 07 / 19 / 2019

Articles

Mechanisms of Hepatic Cholestatic Drug Injury

REVIEW ARTICLE

Mechanisms of Hepatic Cholestatic Drug Injury

Tea Omanović Kolarić1,2, Vjera Ninčević1,2, Robert Smolić1, Martina Smolić*1,2 and George Y Wu3

1Department of Pharmacology, Faculty of Medicine Osijek, Osijek, Croatia
2Department of Pharmacology, Faculty of Dental Medicine and Health, Osijek, Croatia
3Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA
*Correspondence to: Martina Smolic, Department of Pharmacology, Faculty of Medicine Osijek, J. Huttlera 4, Osijek 31000, Croatia. Tel: +38-531512800, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(1):86-92 DOI: 10.14218/JCTH.2018.00042
Received: July 5, 2018 Accepted: February 8, 2019 Published online: March 25, 2019

Abstract

Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.

Keywords

Drug-induced liver injury, Bile acids, Cholestasis

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 86-92  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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