Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Friday, 07 / 19 / 2019

Articles

High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases

ORIGINAL ARTICLE

High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases

Krishnasamy Narayanasamy#*,1, Rajendran Karthick#*,2 and A. Koodal Raj2

1Department of Hepatology, Madras Medical College, Chennai, Tamil Nadu, India
2Multidisciplinary Research Unit (MRU), Madras Medical College, Chennai, Tamil Nadu, India
#These two authors contributed equally to this study.
*Correspondence to: Krishnasamy Narayanasamy, Department of Hepatology, Madras Medical College, Chennai, Tamil Nadu 600003, India. Tel: +91-9841170145, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Rajendran Karthick, Multidisciplinary Research Unit (MRU), Madras Medical College, Chennai, Tamil Nadu 600003, India. Tel: +91-9790787578, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(1):15-20 DOI: 10.14218/JCTH.2018.00018
Received: March 7, 2018 Accepted: September 24, 2018 Published online: October 26, 2018

Abstract

Background and Aims: Although hypovitaminosis D is common among patients with chronic liver disease (CLD), the data are inconsistent on its prevalence and its relationship with CLD. This study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction, and calcium (Ca), phosphate (PO4) and parathyroid hormone (PTH) levels in CLD.

Methods: The study included 236 CLD patients attending the Department of Hepatology, Rajiv Gandhi Government General Hospital (Chennai, India). Serum levels of 25-hydroxyvitamin D (25(OH)D), PTH, Ca, and PO4 were estimated. Severity of liver dysfunction was graded using the Child–Turcotte–Pugh (CTP) score.

Results: The first report from our population showed that 162 of 236 (68.6%) CLD patients had hypovitaminosis D (25(OH)D levels of <30 ng/mL), with higher frequency (124/162) 76.5% among CTP B, C patients. Significant negative correlation (r = −0.288, p = 0.0001) between 25(OH)D and CTP scores was noted in hypovitaminosis D conditions. Level of 25(OH)D was correlated negatively with PTH (r = −0.537, p = 0.0001), positively with Ca (r = 0.657, p = 0.0001), and positively with PO4 (r = 0.477, p = 0.0001) in sufficient vitamin D conditions.

Conclusions: Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in CLD. Timely measurement of vitamin D levels is essential, along with levels of PTH, Ca and PO4, to manage CLD patients.

Keywords

Hypovitaminosis D, Chronic liver disease, Liver dysfunction, Hypocalcemia, Vitamin D

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 15-20  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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