Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 05 / 25 / 2019

Articles

A Meta-analysis of the Value of vWF in the Diagnosis of Liver Cirrhosis with Portal Hypertension

ORIGINAL ARTICLE

A Meta-analysis of the Value of vWF in the Diagnosis of Liver Cirrhosis with Portal Hypertension

Xiang-Chun Ding#,1, Wan-Long Ma#,1, Ming-Kun Li#,2, Shuai-Wei Liu1, Xiao-Yan Liu1, Long Hai1, Xia Luo1, Yan-Chao Hu1 and Li-Na Ma*,1

1Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
2Department of Gastroenterology, Municipal Hospital Affiliated to Xuchang, Xuchang, Henan, China
#These authors contributed equally to this work.
*Correspondence to: Dr. Li-Na Ma, Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China. Tel: +86-13619511758, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2019;7(1):3-8 DOI: 10.14218/JCTH.2018.00036
Received: June 10, 2018 Accepted: September 14, 2018 Published online: November 12, 2018

Abstract
Background and Aims: Studies have indicated that serum von Willebrand factor (vWF) has a positive correlation with hepatic venous pressure gradient. However, information on the value of vWF in the diagnosis of liver cirrhosis with portal hypertension has been lacking. The purpose of this meta-analysis was to assess the value of vWF in the diagnosis of liver cirrhosis with portal hypertension.

Methods: Studies that analyzed the sensitivity, specificity, diagnostic odds ratio combined with likelihood ratios and test for heterogeneity of vWF in the diagnosis of liver cirrhosis with portal hypertension were found in the Cochrane Library, Ovid, VOS-SCI, CNKI, PubMed, Medline, EMBASE, CMB and Wanfang databases. In the end, the data was used to draw the summary receiver operating characteristic curve and to calculate the area under the curve.

Results: Four studies involving 662 patients were analyzed. The results showed that serum vWF in liver cirrhosis with portal hypertension were significantly higher than in those without portal hypertension. Sensitivity combined was 0.823 (95% CI: 0.788, 0.855). Specificity combined was 0.782 (95% CI: 0.708, 0.845). +LR combined was 3.777 (95% CI: 2.794, 5.107). -LR combined was 0.221 (95% CI: 0.180, 0.272). Diagnostic odds ratio combined was 18.347 (95% CI: 11.725, 28.708). The area under the curve was 0.8896.

Conclusions: Serum vWF can be used as an effective and feasible method for noninvasive diagnosis of liver cirrhosis with portal hypertension. However, further studies are still needed to evaluate the severity of liver cirrhosis with portal hypertension.

Keywords
Liver cirrhosis, Portal hypertension, HVPG, vWF

 

 

 

Journal of Clinical and Translational Hepatology 2019 vol. 7, 3-8  [ Html  ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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