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Healthy Donor Fecal Microbiota Transplantation for Recurrent Bacterial Cholangitis in Primary Sclerosing Cholangitis – A Single Case Report

CASE REPORT

Healthy Donor Fecal Microbiota Transplantation for Recurrent Bacterial Cholangitis in Primary Sclerosing Cholangitis – A Single Case Report

Cyriac Abby Philips*,1, Philip Augustine2 and Nikhil Phadke3

1The Liver Unit, Cochin Gastroenterology Group, P.A.A., Ernakulam Medical Centre, National Highway Bypass (NH-66), Palarivattom, Kochi, Kerala, India
2Gastroenterology, Cochin Gastroenterology Group, P.A.A., Ernakulam Medical Centre, National Highway Bypass (NH-66), Palarivattom, Kochi, Kerala, India
3Molecular, Cellular and Developmental Biology, Genepath Dx, Phadke Hospital, Shivajinagar, Pune, Maharashtra, India

*Correspondence to: Cyriac Abby Philips, The Liver Unit, Cochin Gastroenterology Group, P.A.A., Ernakulam Medical Centre, National Highway Bypass (NH-66), 35/194 B, Symphony, Automobile Rd, Palarivattom, Kochi, Kerala 682025, India. Tel: +91-9207745776, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(4):438-441 DOI: 10.14218/JCTH.2018.00033
Received: May 18, 2018 Accepted: July 13, 2018 Published online: August 1, 2018

Abstract

Recurrent acute bacterial cholangitis is a unique indication for liver transplantation in primary sclerosing cholangitis. We present the first report on utility of healthy donor fecal transplantation for management of recurrent acute bacterial cholangitis in a primary sclerosing cholangitis patient. We demonstrate the striking liver biochemistry, bile acid and bacterial community changes following intestinal microbiota transplantation associated with amelioration of recurrent cholangitis.

Keywords

FMT, Sclerosing cholangitis, Stool transplant, Gut microbiome, Microbiota

 

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 438-441  [ Html ] [ PDF Full-text ]

 

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