Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 04 / 20 / 2019

Articles

Evidence for Viral Induction of Biliary Atresia: A Review

REVIEW ARTICLE

Evidence for Viral Induction of Biliary Atresia: A Review

Leon D. Averbukh*, and George Y. Wu

Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA

*Correspondence to: Leon D. Averbukh, Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, 236 Farmington Ave., Farmington, CT 06030, USA. Tel: +1-347-306-4752, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(4):410-419 DOI: 10.14218/JCTH.2018.00046
Received: July 29, 2018 Accepted: September 7, 2018 Published online: November 14, 2018

Abstract

Biliary atresia (BA) is a childhood disease which manifests with abnormal narrowing, blockage or complete absence of bile ducts within the liver. Many possible etiologies have been reported for the development of BA, including congenital, perinatal and acquired conditions. Since the 1970’s, there has been increasing evidence linking BA development to viral perinatal infections. The viral vectors most commonly implicated include members of the herpesviridae family (cytomegalovirus and Epstein-Barr virus) as well as those of the reoviridae family (reovirus and rotavirus). While extensive work has been done on a murine model of disease, the current review focuses primarily on evidence from human studies of viral vectors in children afflicted with BA.

Keywords

Biliary atresia, Cytomegalovirus, Epstein-Barr virus, Reovirus, Rotavirus

 

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 410-419  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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