Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Sunday, 12 / 16 / 2018

Articles

Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma

CASE REPORT

Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma

Düriye Betül Yılmaz, Zeynep Bayramoğlu, Gülşah Ünay, Erdem Ayık, Cumhur İbrahim Başsorgun and Gülsüm Özlem Elpek

Department of Pathology, Akdeniz University Medical School, Konyaalti/Antalya, Turkey

*Correspondence to: Gülsüm Özlem Elpek, Department of Pathology, Akdeniz University Medical School Hospital, Dumlupinar Street, Pinarbasi District, Konyaalti/Antalya-07070, Turkey. Tel: +90-242-249-6389, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(3):339-344 DOI: 10.14218/JCTH.2017.00076
Received: November 29, 2017 Accepted: April 6, 2018 Published online: June 28, 2018

Abstract

The composite tumors of the liver are very rare, including the coexistence of HCC (hepatocellular carcinoma) with NEC (neuroendocrine carcinoma). The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics, behaviors and treatments. Herein is described an incidental collision tumor of HCC-NEC, along with a review of the literature focusing on their clinicopathological findings and prognosis. The tumor presented here was found incidentally in the hepatectomy specimen of a 56-year-old man who had undergone liver transplantation for rapidly progressive liver failure because of alcoholic hepatitis and cirrhosis. Imaging and laboratory examinations did not demonstrate tumor-related findings. During macroscopic examination, two sharply defined and distinctive areas (1.7 cm and 0.6 cm dimension respectively) were detected among the cirrhotic nodules. The characteristic histopathological features and immunohistochemical findings allowed a diagnosis of HCC-NEC to be made. There was no evidence of recurrence and metastasis after 10 months following surgery. The present case and review revealed that these tumors are frequently found in older ages and males. Although serum markers are valuable in the discrimination of malignant tumors, their absence cannot completely rule out composite HCC-NEC. Diagnosis requires a comprehensive histopathological evaluation together with immunohistochemistry. The NEC component might influence the treatment strategy and eventually the outcome of the patient. In conclusion, the rare occurrence of HCC-NEC and the lack of diagnostic clinical signs and symptoms do not exclude their consideration in the differential diagnosis of liver tumors, especially in patients with the chronic liver disease.

Keywords

Liver neoplasm, Hepatocellular carcinoma, Neuroendocrine carcinoma

 

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 339-344  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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