Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Sunday, 12 / 16 / 2018

Articles

Role of SREBPs in Liver Diseases: A Mini-review

REVIEW ARTICLE

Role of SREBPs in Liver Diseases: A Mini-review

Azam Moslehi*, and Zeinab Hamidi-zad

Department of Physiology, Cellular & Molecular Research Center, Qom University of Medical Sciences, Qom, Iran

*Correspondence to: Azam Moslehi, Department of Physiology, Cellular & Molecular Research Center, Qom University of Medical Sciences, Qom 3713649373, Iran. Tel/fax: +98-25-37832470, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(3):332-338 DOI: 10.14218/JCTH.2017.00061
Received: September 18, 2017 Accepted: February 11, 2018 Published online: May 4, 2018

Abstract

Sterol regulator element binding proteins (SREBPs) are a family of transcription factors involved in the biogenesis of cholesterol, fatty acids and triglycerides. They also regulate physiological functions of many organs, such as thyroid, brain, heart, pancreas and hormone synthesis. Beside the physiological effects, SREBPs participate in some pathological processes, diabetes, endoplasmic reticulum stress, atherosclerosis and chronic kidney disease associated with SREBP expression changes. In the liver, SREBPs are involved in the pathogenesis of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatitis and hepatic cancer. There are several SREBP inhibitors that have potential for treating obesity, diabetes and cancer. This review assesses the recent findings about the roles of SREBPs in the physiology of organs’ function and pathogenesis of liver diseases.

Keywords

SREBP, Liver, Lipid

 

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 332-338  [ Html ] [ PDF Full-text ]

 

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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