Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 08 / 16 / 2018

Articles

Noninvasive Quantitative Detection Methods of Liver Fat Content in Nonalcoholic Fatty Liver Disease

REVIEW ARTICLE

Noninvasive Quantitative Detection Methods of Liver Fat Content in Nonalcoholic Fatty Liver Disease

Shujing Lv#,1, Sushan Jiang#,1, Shousheng Liu2,3, Quanjiang Dong3,4, Yongning Xin*,1,2,4,5 and Shiying Xuan*,1,2,4

1Medical College of Qingdao University, Qingdao, Shandong, China
2Digestive Disease Key Laboratory of Qingdao, Qingdao, Shandong, China
3Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong, China
4Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong, China
5Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao, Shandong, China

#These two authors contributed equally to this work.
*Correspondence to: Shiying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, China. Tel: +86-532-88905508, Fax: +86-532-88905293, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; Yongning Xin, Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, Shandong, China. Tel: +86-532-82789463, Fax: +86-532-85968434, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(2):217-221 DOI: 10.14218/JCTH.2018.00021
Received: March 22, 2018 Accepted: June 14, 2018 Published online: June 22, 2018

Abstract

Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis to NAFLD-related liver cirrhosis and is a main cause of chronic liver diseases. Patients with nonalcoholic steatohepatitis and fibrosis are at a great risk of the progression to cirrhosis or hepatocellular carcinoma, both of which are tightly associated with liver-related mortality. Liver biopsy is still the gold standard for the diagnosis of NAFLD, but some defects, such as serious complications, sampling error and variability in histologic evaluation among pathologists, remain problematic. Therefore, noninvasive, repeatable and accurate diagnostic methods are urgently needed. Ultrasonography is a well-established and lower-cost imaging technique for the diagnosis of hepatic steatosis, especially suitable for population census, but limited by its low sensitivity to diagnose mild steatosis and being highly operator-dependent. Computed tomography also lacks the sensitivity to detect mild steatosis and small changes in fat content, and presents a potential radiation hazard. Controlled attenuation parameter based on the FibroScan® technology is a promising tool for noninvasive semiquantitative assessment of liver fat content, but the accuracy rate depends on the operator’s expertise and is affected by age, width of the intercostal space, skin capsular distance and body mass index. Magnetic resonance imaging and magnetic resonance spectroscopy are regarded as the most accurate quantitative methods for measuring liver fat content in clinical practice, especially for longitudinal follow up of NAFLD patients. In this review, we mainly introduce the current imaging methods that are in use for evaluation of liver fat content and we discuss the advantages and disadvantages of each method.

Keywords

Nonalcoholic fatty liver disease, Hydrogen-1 magnetic resonance spectroscopy, Noninvasive, Liver fat content

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 217-221  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

 logo

You are here: Home