Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 10 / 18 / 2018

Articles

Non-invasive in vivo Imaging Grading of Liver Fibrosis

REVIEW ARTICLE

Non-invasive in vivo Imaging Grading of Liver Fibrosis

Hanyu Jiang#, Tianying Zheng#, Ting Duan, Jie Chen and Bin Song*

Department of Radiology, Sichuan University West China Hospital, Chengdu, China

#These authors contributed equally to this work.
*Correspondence to: Bin Song, Department of Radiology, Sichuan University West China Hospital, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, China. Tel: +86-28-85423680, +86-13881918066, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(2):198-207 DOI: 10.14218/JCTH.2017.00038
Received: June 5, 2017 Accepted: November 29, 2017 Published online: January 5, 2018

Abstract

Liver fibrosis (LF), a common consequence of chronic liver diseases with various etiologies, is characterized by excessive accumulation of macromolecules, including collagen, glycoproteins and proteoglycans, in the liver. LF can result in hepatic dysfunction, cirrhosis, portal hypertension and, in some cases, hepatocellular carcinoma. As the current gold standard for diagnosing LF, liver biopsy, however, is invasive and prone to sampling errors and procedure-related complications. Therefore, developing noninvasive, precise and reproducible imaging tests for diagnosing and staging LF is of great significance. Conventional ultrasound (US), computed tomography (CT) and magnetic resonance (MR) imaging can depict morphological alterations of advanced LF, but have relatively limited capability characterizing early-stage LF. In order to optimize the diagnostic performances of noninvasive imaging techniques for LF across its entire spectrum of severity, a number of novel methods, including US elastography, CT perfusion imaging and various MR imaging–based techniques, have been established and introduced to clinical practice. In this review, we intended to summarize current noninvasive imaging techniques for LF, with special emphasis on the possible roles, advantages and limitations of the new emerging imaging modalities.

Keywords

Liver cirrhosis, Ultrasonography, Computed tomography, Magnetic resonance imaging

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 198-207  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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