Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 04 / 21 / 2018

Articles

Update on Liver Failure Following Hepatic Resection: Strategies for Prediction and Avoidance of Post-operative Liver Insufficiency

REVIEW ARTICLE

Update on Liver Failure Following Hepatic Resection: Strategies for Prediction and Avoidance of Post-operative Liver Insufficiency

Amir A. Rahnemai-Azar1, Jordan M. Cloyd2, Sharon M. Weber1, Mary Dillhoff2, Carl Schmidt2, Emily R. Winslow1 and Timothy M. Pawlik*,2

1Department of Surgery, Division of Surgical Oncology, University of Wisconsin Hospital, Madison, WI, USA
2Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

*Correspondence to: Timothy M. Pawlik, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, Department of Surgery, Wexner Medical Center, Ohio State University, 395 W. 12th Ave., Suite 670, Columbus, OH 43210, USA. Tel: +1-614 293 8701, Fax: +1-614 293 4063, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(1):97-104 DOI: 10.14218/JCTH.2017.00060
Received: September 15, 2017 Accepted: October 23, 2017 Published online: November 30, 2017

Abstract

Liver resection is increasingly used for a variety of benign and malignant conditions. Despite advances in preoperative selection, surgical technique and perioperative management, posthepatectomy liver failure (PHLF) is still a leading cause of morbidity and mortality following liver resection. Given the devastating physiological consequences of PHLF and the lack of effective treatment options, identifying risk factors and preventative strategies for PHLF is paramount. In the past, a major limitation to conducting high quality research on risk factors and prevention strategies for PHLF has been the absence of a standardized definition. In this article, we describe relevant definitions for PHLF, discuss risk factors and prediction models, and review advances in liver assessment tools and PHLF prevention strategies.

Keywords

Complication, Hepatectomy, Liver failure, Liver resection, Prevention, Risk models

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 97-104  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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