Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Friday, 09 / 21 / 2018

Articles

Alcoholic Hepatitis: Lost in Translation

REVIEW ARTICLE

Alcoholic Hepatitis: Lost in Translation

Benjamin L. Woolbright*, and Hartmut Jaeschke

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA

*Correspondence to: Benjamin L. Woolbright, Department of Urology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. Tel: +1-913-574-0342, Fax: +1-913-588-7501, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(1):89-96 DOI: 10.14218/JCTH.2017.00054
Received: August 11, 2017 Accepted: November 20, 2017 Published online: December 17, 2017

Abstract

Alcoholic hepatitis is the most severe and acute form of alcoholic liver disease. The mortality rate associated with alcoholic hepatitis is high, largely due to the lack of suitable pharmacological interventions. While there has been substantial research in the area, generating pharmacological interventions has been plagued by the lack of a robust mouse model both for testing and for understanding the underlying pathology. A number of major notable advances have been made in this area recently, with the goal of generating a mouse model of alcoholic hepatitis. The purpose of this article is to review recent advances in modeling alcoholic liver disease both in vitro and in vivo in the mouse, and place them in the context of the greater spectrum of alcoholic liver disease, with a focus on how we can translate current advances into a high-fidelity model of alcoholic hepatitis. In addition, we will review the basic mechanisms of alcoholic hepatitis as it is currently understood, focusing on recent advancements in diagnosis, prognosis and current pathophysiology, especially as it relates to the profound immune dysfunction present during alcoholic hepatitis.

Keywords

Alcoholic hepatitis, Alcohol, Liver disease, Cirrhosis, Prognosis, Keratin-18

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 89-96  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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