Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 07 / 23 / 2018

Articles

Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field

REVIEW ARTICLE

Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field

Xiaobo Xu#,1, Yiling Chen#,2, Ruiqing Zhang3, Xudong Miao4 and Xinhua Chen*,1

1Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
2Department of Anatomy, Tianjin Medical University, Tianjin, China
3Hepatobiliary & Hydatid Department, Digestive and Vascular Surgery Centre, Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
4Department of Orthopedics, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
#These two authors contributed equally to this study.

*Correspondence to: Xinhua Chen, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang 310003, China. Tel: +86-571-87236570, Fax: +86-571-87236466, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(1):85-88 DOI: 10.14218/JCTH.2017.00042
Received: June 20, 2017 Accepted: September 6, 2017 Published online: October 27, 2017

Abstract
Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma (HCC). The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated HCC. This manuscript explores the most recent studies to indicate its unique anti-tumor immune response. The possible immune mechanism, termed as nano-pulse stimulation, was also analyzed.

Keywords
Locoregional therapy, Hepatocellular carcinoma (HCC), Nanosecond pulsed electric field (nsPEF), Nano-pulse stimulation (NPS)

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 85-88  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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