Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Saturday, 04 / 21 / 2018

Articles

Hepatitis C Virus and Hepatocellular Carcinoma: A Narrative Review

REVIEW ARTICLE

Hepatitis C Virus and Hepatocellular Carcinoma: A Narrative Review

Page Axley1, Zunirah Ahmed1, Sujan Ravi1 and Ashwani K. Singal*,2

1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
2Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, AL, USA

*Correspondence to: Ashwani K. Singal, Division of Gastroenterology and Hepatology, University of Alabama Birmingham, AL 35294-0012, USA. Tel: +1-205-975-9698, Fax: +1-205-975-0961, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(1):79-84 DOI: 10.14218/JCTH.2017.00067
Received: October 13, 2017 Accepted: November 20, 2017 Published online: December 17, 2017

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of liver-related death worldwide. Hepatitis C virus (HCV) infection is a major cause of advanced hepatic fibrosis and cirrhosis, with significantly increased risk for development of HCC. The morbidity and mortality of HCV-related HCC remains high, as rates of HCV cirrhosis continue to increase. The long-term goal of antiviral therapy for chronic HCV is to reduce complications from cirrhosis, including HCC. The advent of new direct-acting antivirals with high rates of virological clearance has revolutionized cure of HCV infection. While the development of HCC in HCV patients who achieve disease sustained virologic response is reduced, these patients remain at risk for HCC, particularly those patients with advanced fibrosis and cirrhosis. This review outlines the epidemiology of HCC in chronic HCV, various mechanisms, risk factors and pathophysiology that contribute to this disease process, screening recommendations, and the available data on the impact of new direct-acting antiviral treatment on the development on HCC.

Keywords
Hepatitis C, Hepatocellular carcinoma, Direct-acting antiviral, Viral hepatitis

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 79-84  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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