Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 07 / 23 / 2018

Articles

Hepatitis E: Still Waters Run Deep

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Hepatitis E: Still Waters Run Deep

Moritz von Wulffen1, Dirk Westhölter1, Marc Lütgehetmann2 and Sven Pischke*,1

1Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Institute for Medical Microbiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

*Correspondence to: Sven Pischke, Department of Medicine I, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany. Tel: +49-40-7410-53910, Fax: +49-40-7410-58531, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(1):40-47 DOI: 10.14218/JCTH.2017.00030
Received: April 30, 2017 Accepted: August 19, 2017 Published online: September 21, 2017

Abstract
Hepatitis E is an infectious inflammatory disease of the liver caused by the hepatitis E virus (HEV), a single-stranded RNA virus. Today, it is estimated that there are more than 20 million HEV infections every year, leading to 3.3 million symptomatic cases and more than 56,000 deaths. For a long time it was believed that HEV was a travel-associated disease, endemic in developing countries with poor hygienic standards and unsafe water supply. However, over the past years, publications have demonstrated that autochthonous HEV infections in industrialized countries are far more common than previously thought. Awareness for HEV amongst health care practitioners in industrialized countries is still limited. This relatively rare disease is of great importance, especially in immunocompromised patients where it can cause chronic liver disease. This article comprehensively reviews current literature to give an overview on clinically important topics. It will focus on epidemiological aspects, acute and chronic HEV infection as well as extra-hepatic manifestations, diagnostic approach and treatment options. Furthermore, the article is concluded with a brief outlook on perspectives and urgent problems to be addressed in the future.

Keywords
Hepatitis E, Hepatitis E virus (HEV), Ribavirin, Transplantation, Extrahepatic

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 40-47  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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