Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Thursday, 08 / 16 / 2018

Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease

ORIGINAL ARTICLE

Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease

Zubia Jamil*,1, Sharmin Arif1, Anum Khan1, Asghar Aurangzeb Durrani2 and Nayyar Yaqoob2

1Department of Medicine, Foundation University Medical College, Islamabad, Pakistan
2Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan

*Correspondence to: Zubia Jamil, Department of Medicine, Foundation University Medical College, House No 98, Street No 18, Phase 6 Bahria Town, Islamabad 44000, Pakistan. Tel: +92-3225030457, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2018;6(2):135-140 DOI: 10.14218/JCTH.2017.00055
Received: August 13, 2017 Accepted: December 12, 2017 Published online: February 1, 2018

Abstract

Background and Aims: Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients.

Methods: Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels.

Results: Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (p >0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5, p <0.05). On univariate and multinomial regression analyses, age, female sex, MELD and Child-Pugh class were predictors of low vitamin D levels. Age, model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin D levels (p <0.05).

Conclusions: Vitamin D deficiency is notably related to age, female sex and model of end-stage liver disease score, in addition to Child-Pugh class of liver cirrhosis. Vitamin D levels should be routinely checked in patients with advanced liver cirrhosis (Child-Pugh class B and C) and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients.

Keywords

Vitamin D deficiency, Liver cirrhosis, Osteodystrophy, Liver disease, Skeletal manifestations

 

 

Journal of Clinical and Translational Hepatology 2018 vol. 6, 135-140  [ Html ] [ PDF Full-text ]

© The Authors 2018. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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