Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 12 / 10 / 2018

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Hepatitis E: A Literature Review

REVIEW ARTICLE

Hepatitis E: A Literature Review

Juliana Ayres de Alencar Arrais Guerra*,, Katia Cristina Kampa, Daphne Gonçalves Benatti Morsoletto, Alcindo Pissaia Junior and Cláudia Alexandra Pontes Ivantes

Nossa Senhora das Graças Hospital, Alcides Munhoz Street, 433 – Mercês, Curitiba – PR, Brazil

*Correspondence to: Juliana Ayres de Alencar Arrais Guerra, Nossa Senhora das Graças Hospital, Alcides Munhoz Street, 433 – Mercês, Curitiba – PR 80810-040, Brazil. Tel: +55-41-3240-6060, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2017;5(4):376-383 DOI: 10.14218/JCTH.2017.00012

Received: February 24, 2017 Accepted: July 20, 2017 Published online: August 18, 2017

Abstract

Hepatitis E is the fifth known form of human viral hepatitis. Although not very common in our clinical practice, the incidence in Western countries is increasing. Infection with the hepatitis E virus (HEV) may be related to acute illness, liver failure, chronic hepatitis and cirrhosis. HEV itself is an RNA virus, with eight described genotypes (HEV 1–8), four of which more commonly affect humans and have, thus, been better studied. Besides liver manifestations, genotype 3 is also related to extra-hepatic manifestations, such as neurological, renal and rheumatological. Evolution to chronic disease occurs especially in patients who underwent transplantation, have hematological malignancies requiring chemotherapy, or have infection with the human immunodeficiency virus. The diagnosis may be difficult because of the low availability of tests and due to low sensibility and specificity. The acute form of illness does not have to be treated, but the chronic one does. We present here a literature review of hepatitis E and the relation between chronic hepatitis E and transplantation.

Keywords

Hepatitis E, Chronic hepatitis E, Immunosuppression, Transplantation

 

Journal of Clinical and Translational Hepatology 2017 vol. 5, 376-383 Html ] [ PDF Full-text ]

© The Authors 2017. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

 

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