Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology

Monday, 06 / 25 / 2018

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Clinical Application of Vibration Controlled Transient Elastography in Patients with Chronic Hepatitis B

REVIEW ARTICLE

Clinical Application of Vibration Controlled Transient Elastography in Patients with Chronic Hepatitis B

Xie-Er Liang and Yong-Peng Chen*,

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China

*Correspondence to: Yong-Peng Chen, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Tel: +86-20-62787432, Fax: +86-20-62786530, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal of Clinical and Translational Hepatology 2017;5(4):368-375 DOI: 10.14218/JCTH.2017.00006

Received: January 18, 2017 Accepted: June 26, 2017 Published online: July 26, 2017

Abstract

Evaluation of the extent and progression of liver fibrosis and cirrhosis is of critical importance in the management and prognosis of patients with chronic hepatitis B. Due to the limitation of liver biopsy, non-invasive methods, especially liver stiffness measurement (LSM) by vibration controlled transient elastography, have been developed and widely applied for liver fibrosis assessment. LSM aims to reduce, but not to substitute, the need for liver biopsy for fibrosis/cirrhosis diagnosis. While LSM may have potential utility in monitoring treatment response, its applications in prediction of liver complications in terms of portal hypertension and esophageal varices, as well as disease prognosis, have been gradually validated. Here, we review the latest clinical applications of LSM in patients with chronic hepatitis B.

Keywords

Hepatitis B, Liver fibrosis, Liver stiffness, Transient elastography

 

Journal of Clinical and Translational Hepatology 2017 vol. 5, 368-375 Html ] [ PDF Full-text ]

© The Authors 2017. This article is published under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

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